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nonlinear mixed-effects modeling method by nonmem version 7.5.0  (ICON plc)

 
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    ICON plc nonlinear mixed-effects modeling method by nonmem version 7.5.0
    Nonlinear Mixed Effects Modeling Method By Nonmem Version 7.5.0, supplied by ICON plc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/nonlinear+mixed-effects+modeling+method/nonlinear+mixed+effects+modeling+software+nonmem+version+7+4+4/pm35461968-142-15-22
    Average 90 stars, based on 1 article reviews
    nonlinear mixed-effects modeling method by nonmem version 7.5.0 - by Bioz Stars, 2026-11
    90/100 stars

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    Article Snippet: Although in-vivo bioequivalence (BE) study serves as a golden standard for establishing interchangeability of oral dosage forms, it remains challenging for products with high inter-subject variability such as mesalazine enteric-coated tablet to fulfil the BE criteria set by regulatory authorities.. Mesalazine, as a BCS class IV drug, targets to be delivered to distal ileum or colon with a pH-sensitive polymer coating for the remission of ulcerative colitis.. Through population pharmacokinetic (PK) analysis and in-vitro in-vivo correlation (IVIVC) modeling on the dissolution and BE data of a generic enteric-coated product (EM) and its reference Salofalk® 250 mg tablet (SM), we for the first time revealed the underlying mechanism of the high inter-subject variability for such delayed-release formulation.



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    Vancomycin PPK model studies in adult patients by the nonlinear mixed-effects modeling method.

    Journal: Scientific Reports

    Article Title: Population pharmacokinetic modeling and clinical application of vancomycin in Chinese patients hospitalized in intensive care units

    doi: 10.1038/s41598-021-82312-2

    Figure Lengend Snippet: Vancomycin PPK model studies in adult patients by the nonlinear mixed-effects modeling method.

    Article Snippet: Population pharmacokinetic analysis was performed with 993 serum concentrations versus time from 374 adult patients (294 for model building and 80 for external validation, randomly selected by Kinetica), using a nonlinear mixed-effects modeling method with Kinetica.

    Techniques: